Evolution-adjusted Tumor Pathophysiology:: The Novel by Albrecht Reichle

By Albrecht Reichle

mixed modularized remedies for metastatic melanoma are pointing to valuable difficulties of communique between ‘systems participators’. A communique idea explains 'social engineering', endogenously triggered or via enforcing non-normative boundary stipulations. Evolution-adjusted tumor pathophysiology is borne by way of an evolution concept, which contrasts narrative evolution histories. The device of rationalizations constituting the tumor's normativity (inflammation, immune reaction etc.) represents the non-genomic counterpart of the tumor genome and may be also assessed in the course of tumor staging. Evolution-adjusted tumor pathophysiology permits enforcing utilized platforms biology, a unique medical and pharmaceutical expertise for bioengineering tumor reaction and personalizing tumor treatment. mixed modularized remedy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly tackle genetically established tumor heterogeneity.

Show description

Continue reading

Die Pille und ich: Vom Symbol der sexuellen Befreiung zur by Katrin Wegner

By Katrin Wegner

Die Pille ermöglichte den Frauen einst, sich sexuell zu befreien. Heute dient sie jungen Mädchen dazu, den eigenen Körper nach gängigen Schönheitsvorstellungen zu formen. In ihrem aufrüttelnden Buch zeigt Katrin Wegner, wie die Antibabypille von einem Verhütungsmittel zu einer paintings Lifestyle-Droge geworden ist und welche Risiken damit verbunden sind.
Im Jahr 2010 konsumierten 87 Prozent der 14- bis 17-jährigen Mädchen die Pille. Viele von ihnen nehmen das Medikament jedoch nicht wegen seiner verhütenden Wirkung, sondern aufgrund der ersehnten Nebeneffekte: reinere Haut, volleres, glänzendes Haar und eine größere Oberweite. Die Pharmaindustrie richtet ihr advertising darauf aus und bietet die neuesten Pillen teilweise im trendigen Schminktäschchen an. So wird die Pille zunehmend nicht mehr als Arzneimittel wahrgenommen und eine Abwägung von Risiko und Nutzen findet vor allem bei den Jüngeren kaum noch statt. Katrin Wegner hat mit 250 Frauen aus drei Generationen über die Bedeutung der Pille in ihrem Leben gesprochen. Auf dieser Grundlage zeigt sie, wie sich Liebe, Partnerschaft, Sexualität und Lebensplanung in den letzten fünf Jahrzehnten verändert haben.

Show description

Continue reading

Natural Products in Medicinal Chemistry, Volume 60 (Methods by Stephen Hanessian

By Stephen Hanessian

the foundation supplied through biologically lively usual items to conceive of hybrids, congeners, analogs and unnatural versions is mentioned by way of specialists within the box in sixteen hugely informative chapters.

utilizing well-documented experiences over the last decade, this well timed monograph demonstrates the present value and destiny strength of average items as beginning issues for the advance of latest medicines with greater homes over their progenitors.

The examples are selected for you to characterize a variety of usual items with healing relevance between others, as anticancer brokers, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics.

From the content:
* half I: ordinary items as resources of strength medicinal drugs and Systematic Compound Collections
* half II: From advertised medicines to Designed Analogs and scientific Candidates
* half III: common items as an Incentive for allowing Technologies
* half IV: average items as Pharmacological Tools
* half V: Nature: The supplier, the Enticer, and the Healer

Show description

Continue reading

Immunopharmacology: Proceedings of the Third International by H. O. Schild,M. Rocha E Silva

By H. O. Schild,M. Rocha E Silva

Immunopharmacology is the eleventh quantity of the lawsuits of the 3rd overseas Pharmacological assembly held at Sao Paulo, Brazil on July 26, 1966. the amount covers papers that take care of immunoglobulins accountable for allergic reaction reactions and with the mechanisms of those reactions; pharmacological mediators of rapid and behind schedule hypersensitive reaction; Arthus reactions; and soluble elements published by way of the motion of antigen on sensitized lymphocytes. The publication concludes with a unmarried paper almost about penicillin hypersensitivity. Immunologists and pharmacologists will locate the amount invaluable.

Show description

Continue reading

Controlled Pulmonary Drug Delivery (Advances in Delivery by Hugh D.C. Smyth,Anthony J. Hickey

By Hugh D.C. Smyth,Anthony J. Hickey

The velocity of latest examine and point of innovation many times brought into the sector of drug supply to the lung is mind-blowing given its country of adulthood because the advent of the pressurized metered dose inhaler over a part a century in the past. it really is transparent that our knowing of pulmonary drug supply has now advanced to the purpose that inhalation aerosols could be managed either spatially and temporally to optimize their organic results. those skills contain controlling lung deposition, by means of adopting formula ideas or machine applied sciences, and controlling drug uptake and unencumber via subtle particle applied sciences. the massive variety of contributions to the medical literature and diversity of good texts released lately is proof for the continuing curiosity in pulmonary drug supply study. This reference textual content endeavors to collect the basic thought and perform of managed drug supply to the airlines that's unavailable in different places. Collating and synthesizing the cloth during this swiftly evolving box awarded a problem and finally a feeling of accomplishment that's optimistically mirrored within the content material of the volume.

Show description

Continue reading

Haltbarkeit der Ausgangsstoffe und Rezepturen in der by Karsten Albert,Holger Reimann

By Karsten Albert,Holger Reimann

Die "Verwendbarkeitsfristen von Ausgangsstoffen in der Apotheke" - jetzt auch mit TCM-Drogen!

Stabilität ist eine der wichtigsten Eigenschaften, die ein qualitativ einwandfreies Arzneimittel haben muss. Fragen der Haltbarkeit stellen sich jedoch nicht nur für Fertigarzneimittel und Magistralrezepturen, sondern auch für in der Apotheke gelagerte Ausgangsstoffe.

Das Buch enthält die Verwendbarkeitsfristen von rund 2.500 Arzneistoffen, Hilfsstoffen, Drogen und Zubereitungen, innerhalb derer sie unter Einhaltung der vorgeschriebenen Lagerung zur Herstellung von Arzneimitteln eingesetzt werden können. Darunter sind auch erstmals Angaben zu etwa 270 Drogen der Traditionellen Chinesischen Medizin (TCM). Außerdem werden Vorschläge zur organization und Dokumentation der Haltbarkeitskontrolle von Ausgangsstoffen sowie zur Ermittlung der Haltbarkeit von Rezepturarzneimitteln gemacht.

Dr. Karsten Albert ist Apotheker und ehemaliger Leiter des Laboratoriums des Deutschen Arzneimittel-Codex (DAC). Dr. Holger Reimann ist Fachapotheker für Pharmazeutische Technologie und leitet das Laboratorium des Neuen Rezeptur-Formulariums (NRF).

Show description

Continue reading

Drug Safety Evaluation (Pharmaceutical Development Series) by Shayne Cox Gad

By Shayne Cox Gad

This sensible advisor offers a highway map for protection evaluate as a vital part of the advance of recent medicinal drugs and therapeutics.

•    Helps readers clear up medical, technical, and regulatory matters in preclinical protection review and early medical drug development
•    Explains clinical and philosophical bases for evaluate of particular issues – together with neighborhood tissue tolerance, aim organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity
•    Covers the advance of recent small and big molecules, generics, 505(b)(2) path NDAs, and biosimilars
•    Revises fabric to mirror new drug items (small artificial, huge proteins and cells, and tissues), harmonized worldwide and nationwide rules, and new applied sciences for protection evaluation
•    Adds nearly 20% new and punctiliously updates latest content material from the final edition

Show description

Continue reading

Chemistry for Toxicity Testing by C. W. Jameson,Douglas B. Walters

By C. W. Jameson,Douglas B. Walters

Chemistry for Toxicity checking out provides the chemical specifications for exterior toxicity experiences. This booklet is equipped into 4 elements encompassing 18 chapters that debate the fundamental chemistry concerns for toxicity trying out application. It additionally describes the structure-activity prediction of the carcinogenicity of chemical compounds and the improvement of tools for blending chemical substances in rodent feed.
Some of the themes lined within the booklet are the formulations of insoluble and immiscible try out brokers in liquid medium for toxicity trying out; difficulties of checking out commercial-grade chemical substances; research of dosed feed samples; decision of chemical and automobile combos balance; and the toxicity of inhaled chemical compounds. different elements discover the equipment for new release of try out surroundings and the tracking of vapor focus in attempt surroundings. An overview of dosage research info from a problem-solving perspective is supplied. The dialogue then shifts to the consequences of excellent laboratory practices on chemistry standards for toxicity trying out. the ultimate half is dedicated to the tracking of aerosol chemical compounds inhalation in chambers.
The publication provides valuable details to chemists, toxicologists, scholars, and researchers.

Show description

Continue reading

Handbook of Pharmaceutical Manufacturing Formulations: by Sarfaraz K. Niazi

By Sarfaraz K. Niazi

Over-the-Counter items include a different classification of healthcare items. whereas those formulations have a lot in universal with their prescription opposite numbers, they're offered during this sequence individually as a result of their improvement procedure taken, labeling issues required, and help to be had from providers of components in designing those products.

Highlights from over the counter items, Volume Five include:

  • solids, drinks, and suspensions
  • practical suggestion on tips on how to convey production practices into compliance with regulatory requirements
  • cGMP issues in nice detail
  • a huge variety of formulations of coatings of strong dosage forms

Show description

Continue reading

Outsourcing in Clinical Drug Development by Roy Drucker,Graham Hughes

By Roy Drucker,Graham Hughes

Sponsor businesses and CROs alike will take pleasure in the industry-wide research, sensible, how-to suggestion, and priceless charts and checklists supplied through Outsourcing in medical Drug improvement. A panel of specialists speak about provider id and choice, monetary concerns, and the moral matters. They disguise contracting out laboratory research, information administration, and statistical providers, and the consequences of outsourcing on caliber coverage. even if readers are starting to discover the potential for outsourcing or already fascinated about long term strategic outsourcing partnerships, this useful source is an entire consultant to the drug improvement outsourcing relationship.

Show description

Continue reading